Cell-Mediated Immune Reactivity to Hepatitis Β Surface Antigen in Liver Diseases
نویسندگان
چکیده
منابع مشابه
Cell-mediated immune reactivity in liver disease.
Cell-mediated immunity has been investigated using the leucocyte migration test in 32 patients with chronic active hepatitis or primary biliary cirrhosis. Twenty-six (75%) showed reactivity to liver extract. At least two antigens are involved. Cell-mediated reactivity was confirmed in some cases using lymphocyte ;blast' transformation. There was no correlation with the presence of auto-antibodi...
متن کاملFrequency of hepatitis D virus infection in hepatitis B surface antigen-positive liver diseases.
OBJECTIVE To determine the frequency of HDV among hepatitis B surface antigen (HBsAg)-positive liver disorders. STUDY DESIGN An observational cross-sectional study. PLACE AND DURATION OF STUDY Medical Unit I, Chandka Medical College Hospital, Larkana, from July 2003 to June 2008. METHODOLOGY Adult patients with HBs liver related disorders were evaluated for the presence of delta antibodie...
متن کاملEXPRESSION OF HEPATITIS B SURFACE ANTIGEN IN SACCHAROMYCES CEREVISIAE
The genome of HB V virus of serotype ayw cloned in pBR322 and expression shuttle vector p YES2 were used for construction of the HBsAg chimeric genes and their expression in Saccharomyces cerevisiae. Two recombinant plasmids were constructed. One of them contained the coding sequences for the major polypeptide of surface antigen. Another construct carried the major polypeptide with the pre-S2 a...
متن کاملImmune responses to the hepatitis B surface antigen and liver-specific lipoprotein in acute type B hepatitis.
A serial prospective study of cellular immunity to HBsAg and liver-specific membrane lipoprotein was undertaken in 21 adults with acute hepatitis type B. Cellular immunity to HBsAg as determined by leucocyte migration inhibition with partially purified HBsAg as antigen was detected in all the patients during the recovery phase of the illness and was already detectable at the time of admission i...
متن کاملCell-mediated immunity in guinea pigs to subunits derived from hepatitis B surface antigen.
Guinea pigs immunized wit- hepatitis B surface antigen (HBSAg), types adw and ayw, and with two polypeptides (400,000 and 24,000 molecular weight) developed cell-mediated immunity (CMI), as determined by radioimmunoassay. Peritoneal exudate (PE) cells from guinea pigs immunized with the 40,000-molecular-weight polypeptide migrated poorly (30 to 88% inhibition) after challenge with the immunizin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gastroenterology
سال: 1975
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(19)32570-3